Representative Publications

1. Zhou C*, Li H*, Wang J*, Qian C, Xiong H, Chu Z, Shao Q, Li X, Sun S, Sun K, Zhu A, Wang J, Jin X, Yang F, El-Din T, Li B#, Huang J#, Wu K#, Lu P#. De novo designed voltage-gated anion channels suppress neuron firing. Cell 188 (26), 7495-7511. e21.

✨ Research Highlights
• Highlighted in Research Highlights of Nature Biotechnology. Learn more


2. Zhu J*, Liang M*, Sun K*, Wei Y, Guo R, Zhang L, Shi J, Ma D, Hu Q, Huang G, Lu P#. De novo design of transmembrane fluorescence-activating proteins. Nature 2025 Apr;640(8057):249-257.


3. Mi L*, Li Y*, Lv X*, Wan Z, Liu X, Li H, Yao Y, Zhang L, Xu Z, Zhuang X, Ji K, Jiang M, Wang Y#, Lu P#. Computational design of a high-precision mitochondrial DNA cytosine base editor Nat Struct Mol Biol. 2025.

📰 News & Views
• Featured as an example of how to advance genome‑editing technologies in News & Views of Nature Structural & Molecular Biology. Learn more


4. Sun K*, Li S*, Zheng B*, Zhu Y*, Wang T*, Liang M, Yao Y, Zhang K, Zhang J, Li H, Han D, Zheng J, Coventry B, Cao L, Baker D, Liu L#, Lu P#. Accurate de novo design of heterochiral protein-protein interactions. Cell Res. 2024 Dec;34(12):846-858.

🏆 Awards
• Received the Cell Research Annual Outstanding Paper Award. Learn more


5. Xu C *, Lu P *#, El Din T, Pei X, Johnson M, Uyeda A, Bick M, Xu Q, Jiang D, Bai H, Reggiano G, Hsia Y, Brunette TJ, Dou J, Ma D, Lynch E, Boyken S, Huang P, Stewart L, DiMaio F, Kollman J, Luisi B, Matsuura T, Catterall W#, Baker D#. Computational Design of Transmembrane Pores. Nature, 2020; 585 (7823), 129-134.


6. Lu P, Min D, DiMaio F, Wei KY, Vahey MD, Boyken SE, Chen Z, Fallas JA, Ueda G, Sheffler W, Mulligan VK, Xu W, Bowie JU, Baker D. Accurate computational design of multipass transmembrane proteins. Science. 2018; 359(6379):1042-1046.


7. Lu P*, Bai X*, Ma D*, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Sheres S, Shi Y. Three-dimensional structure of human γ-secretase. Nature. 2014; 512(7513):166-70.


*equal contribution 
#Corresponding author

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