We design proteins, with primary research focused on: 

(1) Design of transmembrane proteins capable of sensing and responding to diverse physical and chemical stimuli, including membrane probes, transporters, ion channels, and receptors.
The team has achieved the precise de novo design of transmembrane pores (Nature, 2020), voltage-gated anion channels that modulate neuronal activity (Cell, 2025), and transmembrane fluorescence-activating proteins for live-cell membrane imaging (Nature, 2025). 

(2) Developing novel proteins to address critical challenges in life sciences and biotechnology, such as mirror-image protein tools, enzymes, protein- and peptide-based therapeutics, and gene-editing systems. 
Notable breakthroughs include the de novo design of heterochiral protein–protein interactions (Cell Research, 2024), the development of broad-spectrum neutralizing mini-proteins effective against multiple subtypes of Clostridioides difficile toxin B with demonstrated in vivo efficacy (Nature Communications, 2024), and the computational design of a high-precision mitochondrial DNA cytosine base editor (Nature Structural & Molecular Biology, 2025).